Hao Chen | 陈浩     Posts     About Me

About Me

Publications

  • “Application of a comprehensive platform technology for detection of cancer-associated genomic alterations and viral DNA in liquid biopsies”. Annals of Oncology, 2018. (Second Author)

  • “An enhanced next-generation sequencing liquid biopsy assay for simultaneous detection of somatic variants, microsatellite instability and viral DNA.”. Journal of Clinical Oncology, 2018. (Second Author)

  • “LDSplitDB: A database for studies of meiotic recombination hotspots in MHC using human genomic data”. BMC Medical Genomics, 2018. (Second Author)

  • “Cytofkit: A Bioconductor Package for an Integrated Mass Cytometry Data Analysis Pipeline”. PLoS Comput Biol, 2016. (First Author)

  • “flowAI: automatic and interactive anomaly discerning tools for flow cytometry”. Bioinformatics, 2016. (Second Author)

  • “ARG-walker: Inference of Individual Specific Strengths of Meiotic Recombination Hotspots by Population Genomics Analysis”. BMC Genomics, 2015. (First Author)

  • “Optimization of production conditions for mushroom polysaccharides with high yield and antitumor activity”. Carbohydrate Polymers, 2012. (Third Author)

Patents

  • “Method for Detection and Quantification of Genetic Alterations”. 10201805450Y, 2018.

  • “Methods for Identifying Clusters in a Dataset, Methods of Analyzing Cytometry Data with the Aid of a Computer and Methods of Detecting Cell Sub-populations in a Plurality of Cells”. US 2017-0371886 A1, 2017.

  • “ModalGATE: An Efficient Gating Algorithm Facilitating Automated and Reproducible Analysis of Flow Cytometry Data”. SIGN/P/09834/00/SG, 2017.

Developed Softwares

R packages

  • cytofkit An integrated analysis pipeline for high-dimensional and high-throughput mass cytometry data. (Ranked among top 20% on Bioconductor, with average 300 download times per month)
  • flowAI Automatic and interactive quality control for flow cytometry data. (Ranked among top 50% on Bioconductor, with average 100 download times per month)
  • ClusterX A tool for visualizing the high-dimensional mass cytometry data as well as automatically detecting cell populations by fast density-based clustering, generally applicable to any multi-parametric data.
  • RphenoGraph R implementation of PhenoGraph , a fast and accurate high-dimensional clustering algorithm.
  • uSORT A self-refining ordering pipeline for gene selection.
  • StackedDensityPlot A flexible and easy-to-use function for building stacked density plot based on ggplot2.

Shiny APP

  • flowAIshinyAPP A web application for interactive quality control of flow cytometry data
  • cytofkitShinyAPP A web application for interactive visualization and exploration of cytofkit analysis results

Perl Tool

  • ARGwalker Ancestral Recombination Graph (ARG) mining based estimation of individual recombination strength